While Sylas was with Gralith, although he spent most of his time on the Rune Inheritance, he also had Gralith teach him about the basics of Rune Mastery as well.
Sylas was in an odd position where he was maybe the most powerful Rune Master in the entire galaxy, at least in the F-Grade, and yet he knew less than some toddlers just getting into training.
He had all the talent in the world, but what he lacked the most was foundation. And unfortunately, that was one thing that he couldn't gain from Gralith in just a few days.
That didn't mean that he couldn't try, though.
What Sylas did end up learning was that there were so many different forms and applications of Rune Mastery that it was probably impossible for a single person to learn them all. The use of Blood Essence was probably one of the largest umbrellas there was, though.
Sylas' Body Refinement method relied on these concepts as well, but as he said, this was just one of the many.